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Home/ Non-Surgical Hair Restoration Treatments/PRP with ACell® Injection Therapy

PRP with ACell® Injection Therapy

Platelet Rich Plasma with ACell injection therapy is the premier non-surgical solution for hair restoration, offering a controlled, professional alternative to over-the-counter products or unsupervised treatments purchased online. Using the patient’s own blood and growth factors, PRP with ACell helps halt hair thinning, strengthen weakened hair, and stimulate new growth. At Leonard Hair Transplant Associates, Dr. Matthew Lopresti incorporates this advanced therapy into personalized treatment plans, combining it with other leading techniques to address each patient’s specific pattern of hair loss and long-term goals

What Is PRP with ACell® Injection Therapy?

PRP with ACell injection therapy is a non-surgical treatment for hair thinning and loss that uses your own blood to stimulate growth in a quick office treatment with little to no downtime. Platelet-rich plasma, or PRP, is a component of blood that contains platelets and growth factors. Those growth factors are like signal callers that give instructions to your tissue to regenerate and multiply.

ACell is an FDA-approved cellular regeneration substance that uses MatriStem® technology. ACell is a naturally occurring material that triggers new blood vessel formation, recruits stem cells, and resorbs, leaving no scar tissue or material behind. By combining PRP with ACell therapy, activation of hair growth is possible in men and women affected by pattern and other forms of hair loss.

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How Is PRP with ACell® Injection Therapy Performed?

PRP with ACell injection therapy is performed in our office and is designed to be efficient, comfortable, and minimally disruptive to your day. Because the treatment uses your own blood components, the process is highly personalized and carefully handled from start to finish to ensure optimal concentration and placement of growth factors. The entire visit typically takes about 30–45 minutes.

Step 1: Preparation of the Scalp

To ensure maximum comfort during the procedure, the treatment area is cleansed and numbed using a local anesthetic. This helps minimize any sensitivity during the injection process.

Step 2: Blood Collection

A small sample of blood is drawn from your arm, similar to a routine laboratory test. Only a small amount is needed to create the platelet-rich plasma required for treatment.

Step 3: PRP Processing

The blood sample is placed into a specialized centrifuge that spins at high speed to separate it into different layers. This process isolates the platelet-rich plasma — the portion of the blood that contains concentrated growth factors responsible for tissue repair and regeneration.

Step 4: Activation with ACell®

The concentrated PRP is then combined with ACell, an FDA-approved cellular regeneration material using MatriStem® technology. ACell helps trigger new blood vessel formation, recruit stem cells, and support a more robust regenerative response.

Step 5: Precise Injection into the Scalp

Using a fine syringe, the PRP with ACell solution is meticulously and strategically injected into areas of thinning hair. The injections are carefully placed to stimulate weakened follicles, improve scalp circulation, and jump-start the body’s natural healing response.

Once introduced into the scalp, PRP with ACell works to increase follicle health and restore hair thickness and strength over time. After your treatment, you should be able to return to your normal daily activities soon afterward with little to no downtime.

What Are the Benefits of PRP with ACell® Injection Therapy?

PRP with ACell injection therapy can drastically slow down the hair loss process and can provide you with thicker hair growth in treated areas. Additionally, this minimally invasive technique can:

What Areas Can Be Treated with PRP with ACell®?

PRP with ACell injection therapy is most commonly used to treat areas of thinning hair on the scalp. This includes the frontal hairline, the temples, the crown (vertex), and to diffuse thinning throughout the scalp. It is often especially beneficial for women experiencing overall thinning and for men in the earlier stages of pattern hair loss. In some cases, PRP with ACell may also be used to improve the quality of existing transplanted hair or support healing after hair transplant surgery.

During your consultation, Dr. Matthew Lopresti or Dr. Mary Lopresti will evaluate the areas of concern and determine whether PRP with ACell is appropriate for your specific pattern of hair loss.

Who Is a Good Candidate for PRP with ACell® Injection Therapy?

If you are noticing the first signs of hair loss, acting now can make all the difference. PRP with ACell injection therapy is most effective when started early, helping protect the hair you still have, strengthen weak follicles, and stimulate new growth before thinning becomes more noticeable.

This treatment works best when paired with other proven hair restoration options, such as Rogaine Foam®, Propecia®, or hair transplant surgery, because it is most effective during the hair’s active growth phase. People in the early stages of hair loss, including women with overall thinning, often see the most significant results. During a consultation, Dr. Matthew Lopresti will evaluate your hair, discuss your goals, and create a personalized plan to protect your hair and maximize growth with PRP with ACell. Starting early is the key to keeping what you have and achieving lasting, natural results.

Patient Success Stories with Platelet Rich Plasma and ACell

WCVB-TV Features Rob Ninkovich and PRP Therapy

Our patient and former NFL player Rob Ninkovich discusses his experience with PRP Therapy in an interview with Emily Riemer from WCVB-TV. Having hair loss run in his family, Rob chose to undergo treatment with Dr. Lopresti to help prevent hair thinning in the future. During the Channel 5 News segment, Dr. Lopresti details how the PRP Therapy process works.

PRP with ACell Therapy Featured on Boston 25 News

During a feature on Boston 25 News, Dr. Lopresti explains the science behind PRP and how the process works. The patient, Pam, recounts her experience with PRP and how treating her thinning hair helped restore her self-confidence. Stories like Pam’s are evidence that PRP can be an especially beneficial solution for women suffering from hair loss, as they often have limited options available.

Read more about Pam’s story

28 Year Old Says PRP with ACell Therapy Gave Him Unbelievable Results

Rich Kelleher always thought hair restoration was just for celebrities and athletes—that is, until he noticed his hair starting to thin and found that most patients are just “regular guys, like me.” At only 28 years old, and knowing his hair loss would continue to progress, Rich decided to meet with Dr. Lopresti to learn about his options. PRP Therapy was ultimately recommended for his case, supplemented with Propecia® and Rogaine Foam®. Although he should continue to see improvement from his treatment, Rich says his results have already been “unbelievable.”

Learn more about Rich’s story.

Female Patient Treats Thinning Hair with PRP and ACell Therapy

As the mother of one of our team’s technicians at Leonard Hair Transplant Associates, Donna was familiar with hair restoration, but she never thought she would need it. Once she reached age 58, however, Donna started noticing more hair left in her brush and in the drain after showering. This motivated her to seek the help of our team for possible female hair loss treatments. Dr. Lopresti determined Donna was a great candidate for PRP Therapy. Since starting PRP, Donna reflects on the process saying, “[It] was fast, easy and painless.” Having experienced thinning hair for five years before getting treatment, Donna says she felt especially “isolated and embarrassed,” as thinning hair is typically more accepted with men than women. Her continuing results have restored her sense of self-confidence, and she hopes her story inspires other women with thinning hair to look into the potential of PRP.

Read more about Donna’s story.

How Do I Prepare for PRP With ACell® Injection Therapy?

On the day of your PRP with ACell treatment, Dr. Lopresti wants his patients to wash their hair thoroughly using regular shampoo the morning of their appointment. Patients should avoid applying heavy hair gel, pomade, or hair fibers to their hair. Staying hydrated is important, so we recommend drinking approximately 16 ounces of water at least 2 hours before your treatment. Finally, we do not want patients exercising on the day of their PRP with ACell treatment, as this may increase your blood pressure and cause swelling.

What Should I Avoid Prior to a PRP with ACell® Treatment?

There are a few things you will need to avoid before PRP with ACell treatment at Leonard Hair Transplant Associates. If you are taking any blood thinners, please let us know as soon as possible as they may represent a contraindication to this treatment. These medications include Plavix, Coumadin, and Heparin. If you are currently taking or have taken Prednisone or steroids, please let us know. We would want to postpone treatment for two weeks after stopping those medications.

Three days prior to PRP with ACell treatment, patients should avoid certain other medications and supplements. These include — but are not limited to — Aspirin, Ibuprofen products, Vitamin A, and Vitamin E. A full list will be provided to patients well in advance of PRP with ACell treatment. Patients should also avoid smoking cigarettes and drinking alcohol for three days before their appointment.

What Should I Expect After PRP with ACell® Injection Therapy?

Most patients resume their normal life activities the very next day. Some soreness on your scalp where the injections were applied is not uncommon and should fade quickly. Patients may begin to see results after four to six months, typically described as less shedding or loss and even thicker, fuller hair in the treated area. Our team will monitor your results and make suggestions to maintain or improve your outcome as it develops. For best results, consistency is key, and Dr. Matthew Lopresti or Dr. Mary Lopresti will discuss repeat treatments with you to ensure you can enjoy your results for months and even years down the line.

When Will I See Results from PRP with ACell® Therapy?

PRP with ACell works by stimulating and strengthening existing hair follicles, which means results develop gradually. Most patients begin to notice reduced shedding within the first few months. Visible improvements in hair thickness and density typically appear around four to six months after treatment, with continued improvement over time.

For best results, consistency is key. You may be recommended a series of treatments followed by maintenance sessions to help preserve and enhance your outcome long term.

Combining PRP with ACell® Therapy and Other Hair Restoration Treatments

PRP with ACell injection therapy can be used alone or in combination with other hair restoration treatments to optimize results.

PRP with ACell injection therapy can be used in combination with hair transplantation surgery to enhance the positive effects achieved from receiving newly grafted hairs. In addition to the benefits of simply undergoing hair transplant surgery, patients can experience faster healing times, stabilization and improved quality of their native hair, as well as minimization of scar tissue formation when adding PRP with ACell injection therapy to their surgical plan.

It can also be combined with medical therapies such as Rogaine Foam® or Propecia® to help maintain existing hair and support follicles that are still active but weakened. Because hair loss is progressive for many individuals, a multi-modal approach often provides the most comprehensive and long-lasting improvement.

During your consultation, Dr. Matthew Lopresti or Dr. Mary Lopresti will recommend a personalized treatment strategy designed to stabilize hair loss, improve scalp health, and promote thicker, healthier hair over time.

Schedule Your PRP with ACell® Therapy Consultation

Have questions about PRP with ACell injection therapy? Contact our practice to find out if this innovative technique can help you.